FBXW5 抗体 (AA 265-494)
Quick Overview for FBXW5 抗体 (AA 265-494) (ABIN7152505)
抗原
See all FBXW5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 265-494
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human F-box/WD repeat-containing protein 5 protein (265-494AA)
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亚型
- IgG
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anti-F-Box and WD Repeat Domain Containing 5 (FBXW5) (AA 324-350) antibody
FBXW5 适用: 人 WB 宿主: 兔 Polyclonal RB40653 unconjugated
anti-F-Box and WD Repeat Domain Containing 5 (FBXW5) (AA 1-159) antibodyFBXW5 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 5 (FBXW5) (AA 184-566) antibodyFBXW5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))
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别名
- FBXW5
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背景
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Background: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.
Aliases: FBXW5 antibody, FBW5 antibody, PP3971F-box/WD repeat-containing protein 5 antibody, F-box and WD-40 domain-containing protein 5 antibody
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UniProt
- Q969U6
抗原
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