BTRC 抗体 (AA 397-448)
Quick Overview for BTRC 抗体 (AA 397-448) (ABIN7152495)
抗原
See all BTRC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 397-448
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human F-box/WD repeat-containing protein 1A protein (397-448AA)
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亚型
- IgG
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anti-beta-Transducin Repeat Containing (BTRC) (AA 24-151) antibody
BTRC 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 4C5D8 unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 50-340) antibodyBTRC 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) antibodyBTRC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 1-605) antibodyBTRC 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (N-Term) antibodyBTRC 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 52-354) antibodyBTRC 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 2H2 unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 17-52), (N-Term) antibodyBTRC 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB16275 unconjugated
anti-beta-Transducin Repeat Containing (BTRC) antibodyBTRC 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 701-1000) antibodyBTRC 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-beta-Transducin Repeat Containing (BTRC) (AA 52-354) antibodyBTRC 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 1F10 unconjugated
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应用备注
- Recommended dilution: WB:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- BTRC (beta-Transducin Repeat Containing (BTRC))
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别名
- BTRC
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背景
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Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at \\\'Lys-21\\\' and \\\'Lys-22\\\'. SCF(BTRC) mediates the ubiquitination of CEP68, this is required for centriole separation during mitosis (PubMed:25704143, PubMed:25503564). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.
Aliases: Beta transducin repeat containing E3 ubiquitin protein ligase antibody, beta TrCP1 antibody, beta-transducin repeat containing antibody, BETA-TRCP antibody, betaTrCP antibody, btrC antibody, bTrCP antibody, bTrCP1 antibody, E3RSIkappaB antibody, F box and WD repeat protein 1B antibody, F box and WD repeats protein beta TrCP antibody, F-box and WD repeats protein beta-TrCP antibody, F-box/WD repeat protein 1A antibody, F-box/WD repeat-containing protein 1A antibody, FBW1A antibody, FBW1A_HUMAN antibody, FBXW1 antibody, FBXW1A antibody, FWD1 antibody, HOS antibody, mKIAA4123 antibody, pIkappaBalpha-E3 receptor subunit antibody, Slimb antibody
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UniProt
- Q9Y297
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途径
- Cell Division Cycle, Hedgehog Signaling
抗原
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