EPH Receptor A8 抗体 (AA 45-249)
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Quick Overview for EPH Receptor A8 抗体 (AA 45-249) (ABIN7151855)
抗原
See all EPH Receptor A8 (EPHA8) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 45-249
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原理
- EPHA8 Antibody
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Ephrin type-A receptor 8 protein (45-249AA)
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亚型
- IgG
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anti-EPH Receptor A8 (EPHA8) (AA 70-150) antibody
EPHA8 适用: 人 ELISA 宿主: 小鼠 Monoclonal 9A12D8 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- EPH Receptor A8 (EPHA8)
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别名
- EPHA8
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背景
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Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).
Aliases: EPHA8 antibody, EEK antibody, HEK3 antibody, KIAA1459Ephrin type-A receptor 8 antibody, EC 2.7.10.1 antibody, EPH- and ELK-related kinase antibody, EPH-like kinase 3 antibody, EK3 antibody, hEK3 antibody, Tyrosine-protein kinase receptor EEK antibody
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UniProt
- P29322
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途径
- RTK signaling
抗原
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