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SYVN1 抗体 (AA 338-487)

This anti-SYVN1 antibody (ABIN7151230) is a Rabbit Polyclonal antibody detecting SYVN1 in ELISA, IHC, IF. Suitable for Human.
产品编号 ABIN7151230
发货至: 中国

Quick Overview for SYVN1 抗体 (AA 338-487) (ABIN7151230)

抗原

See all SYVN1 抗体
SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

适用

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宿主

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克隆类型

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多克隆

标记

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This SYVN1 antibody is un-conjugated

应用范围

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ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
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    AA 338-487

    交叉反应

    纯化方法

    >95%, Protein G purified

    免疫原

    Recombinant Human E3 ubiquitin-protein ligase synoviolin protein (338-487AA)

    亚型

    IgG
  • 应用备注

    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

    别名

    SYVN1

    背景

    Background: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.

    Aliases: 1200010C09Rik antibody, DER3 antibody, E3 ubiquitin-protein ligase synoviolin antibody, HMG coA reductase degradation 1 homolog antibody, HRD1 antibody, KIAA1810 antibody, MGC40372 antibody, OTTHUMP00000230429 antibody, OTTHUMP00000230430 antibody, OTTHUMP00000230431 antibody, OTTHUMP00000230432 antibody, Synovial apoptosis inhibitor 1 antibody, Synovial apoptosis inhibitor 1, synoviolin antibody, Synoviolin 1 antibody, Synoviolin 1 isoform b antibody, SYNOVIOLIN antibody, SYVN1 antibody, SYVN1_HUMAN antibody

    UniProt

    Q86TM6

    途径

    ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
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