SYVN1 抗体 (AA 338-487)
Quick Overview for SYVN1 抗体 (AA 338-487) (ABIN7151230)
抗原
See all SYVN1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 338-487
-
交叉反应
- 人
-
纯化方法
- >95%, Protein G purified
-
免疫原
- Recombinant Human E3 ubiquitin-protein ligase synoviolin protein (338-487AA)
-
亚型
- IgG
-
-
-
-
应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
-
别名
- SYVN1
-
背景
-
Background: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
Aliases: 1200010C09Rik antibody, DER3 antibody, E3 ubiquitin-protein ligase synoviolin antibody, HMG coA reductase degradation 1 homolog antibody, HRD1 antibody, KIAA1810 antibody, MGC40372 antibody, OTTHUMP00000230429 antibody, OTTHUMP00000230430 antibody, OTTHUMP00000230431 antibody, OTTHUMP00000230432 antibody, Synovial apoptosis inhibitor 1 antibody, Synovial apoptosis inhibitor 1, synoviolin antibody, Synoviolin 1 antibody, Synoviolin 1 isoform b antibody, SYNOVIOLIN antibody, SYVN1 antibody, SYVN1_HUMAN antibody
-
UniProt
- Q86TM6
-
途径
- ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
抗原
-