SYVN1 抗体 (AA 338-487)
Quick Overview for SYVN1 抗体 (AA 338-487) (ABIN7151230)
抗原
See all SYVN1 抗体适用
宿主
克隆类型
标记
应用范围
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    - 
                                            抗原表位
- AA 338-487
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                                            交叉反应
- 人
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                                            纯化方法
- >95%, Protein G purified
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                                            免疫原
- Recombinant Human E3 ubiquitin-protein ligase synoviolin protein (338-487AA)
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                                            亚型
- IgG
 
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    - 
                                            应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
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                                            限制
- 仅限研究用
 
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    - 
                                            状态
- Liquid
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                                            缓冲液
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                        Preservative: 0.03 % Proclin 300
 Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
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                                            储存液
- ProClin
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                                            注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            储存条件
- -20 °C,-80 °C
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                                            储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
 
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    - SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
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                                            别名
- SYVN1
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                                            背景
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                        Background: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Aliases: 1200010C09Rik antibody, DER3 antibody, E3 ubiquitin-protein ligase synoviolin antibody, HMG coA reductase degradation 1 homolog antibody, HRD1 antibody, KIAA1810 antibody, MGC40372 antibody, OTTHUMP00000230429 antibody, OTTHUMP00000230430 antibody, OTTHUMP00000230431 antibody, OTTHUMP00000230432 antibody, Synovial apoptosis inhibitor 1 antibody, Synovial apoptosis inhibitor 1, synoviolin antibody, Synoviolin 1 antibody, Synoviolin 1 isoform b antibody, SYNOVIOLIN antibody, SYVN1 antibody, SYVN1_HUMAN antibody 
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                                            UniProt
- Q86TM6
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                                            途径
- ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
 抗原
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