CBLC 抗体 (AA 245-474)
Quick Overview for CBLC 抗体 (AA 245-474) (ABIN7151000)
抗原
See all CBLC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 245-474
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human E3 ubiquitin-protein ligase CBL-C protein (245-474AA)
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亚型
- IgG
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anti-Cbl proto-oncogene C (CBLC) (AA 245-474) antibody
CBLC 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 1-474) antibodyCBLC 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F10 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 244-474) antibodyCBLC 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 3B4 unconjugated
anti-Cbl proto-oncogene C (CBLC) (C-Term) antibodyCBLC 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 1-474) antibodyCBLC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 244-474) antibodyCBLC 适用: 人 WB 宿主: 小鼠 Monoclonal 3D9 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 424-453), (C-Term) antibodyCBLC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0696 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 1-30), (N-Term) antibodyCBLC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0694 unconjugated
anti-Cbl proto-oncogene C (CBLC) antibodyCBLC 适用: 人 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (N-Term) antibodyCBLC 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- CBLC (Cbl proto-oncogene C (CBLC))
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别名
- CBLC
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背景
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Background: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction, upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at \\\'Tyr-419\\\'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation, CD2AP converts it from an inhibitor to a promoter of RET degradation, the function limits the potency of GDNF on neuronal survival.
Aliases: CBLC antibody, CBL3 antibody, RNF57E3 ubiquitin-protein ligase CBL-C antibody, EC 2.3.2.27 antibody, RING finger protein 57 antibody, RING-type E3 ubiquitin transferase CBL-C antibody, SH3-binding protein CBL-3 antibody, SH3-binding protein CBL-C antibody, Signal transduction protein CBL-C antibody
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UniProt
- Q9ULV8
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途径
- EGFR Signaling Pathway
抗原
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