DNA2 抗体 (AA 1-300)
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北京 101111
Quick Overview for DNA2 抗体 (AA 1-300) (ABIN7150306)
抗原
See all DNA2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-300
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原理
- DNA2 Antibody
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human DNA replication ATP-dependent helicase/nuclease DNA2 protein (1-300AA)
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亚型
- IgG
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anti-DNA Replication Helicase 2 Homolog (DNA2) antibody
DNA2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DNA Replication Helicase 2 Homolog (DNA2) (Internal Region) antibodyDNA2 适用: 人, 小鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- DNA2 (DNA Replication Helicase 2 Homolog (DNA2))
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别名
- DNA2
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背景
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Background: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5\'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5\'-ssDNA, while the 3\'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5\'-3\' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5\'-3\' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.
Aliases: DNA replication ATP-dependent helicase-like homolog antibody, DNA replication helicase 2 homolog antibody, DNA replication helicase 2, yeast, homolog of antibody, DNA replication helicase 2-like antibody, DNA replication helicase/nuclease 2 antibody, DNA2 antibody, DNA2-like helicase antibody, DNA2L antibody, DNA2L_HUMAN antibody, HDNA2 antibody, KIAA0083 antibody, PEOA6 antibody, SCKL8 antibody
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UniProt
- P51530
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途径
- Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
抗原
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