DDB2 抗体 (AA 1-185) (HRP)
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北京 101111
Quick Overview for DDB2 抗体 (AA 1-185) (HRP) (ABIN7150131)
抗原
See all DDB2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-185
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原理
- DDB2 Antibody, HRP conjugated
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human DNA damage-binding protein 2 protein (1-185AA)
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亚型
- IgG
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anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) antibody
KD Validated DDB2 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB2805 unconjugated Recombinant Antibody
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (AA 1-315) antibodyDDB2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (AA 201-300) antibodyDDB2 适用: 小鼠, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) antibodyDDB2 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (AA 166-383) antibodyDDB2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) antibodyDDB2 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (AA 1-427) antibodyDDB2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) antibodyDDB2 适用: 人 WB, ICC, DB 宿主: 小鼠 Monoclonal 2246C4a unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) antibodyDDB2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (AA 1-185) antibodyDDB2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
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别名
- DDB2
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背景
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Background: Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.
Aliases: damage-specific DNA binding protein 2 antibody, Damage-specific DNA-binding protein 2 antibody, DDB p48 subunit antibody, Ddb2 antibody, DDB2_HUMAN antibody, DDBb antibody, DNA damage-binding protein 2 antibody, UV-damaged DNA-binding protein 2 antibody, UV-DDB 2 antibody, Xeroderma pigmentosum group E protei antibody
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UniProt
- Q92466
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途径
- DNA Damage Repair
抗原
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