A Disintegrin and Metallopeptidase Domain 1a (ADAM1A) (AA 214-504) 抗体 (Biotin)
Quick Overview for A Disintegrin and Metallopeptidase Domain 1a (ADAM1A) (AA 214-504) 抗体 (Biotin) (ABIN7150035)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 214-504
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Disintegrin and metalloproteinase domain-containing protein 10 protein (214-504AA)
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亚型
- IgG
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anti-A Disintegrin and Metallopeptidase Domain 1a (ADAM1A) (AA 214-504) antibody
ADAM1A 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-A Disintegrin and Metallopeptidase Domain 1a (ADAM1A) (AA 463-727) antibodyADAM1A 适用: 大鼠 IHC, WB, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-A Disintegrin and Metallopeptidase Domain 1a (ADAM1A) (Internal Region) antibodyADAM1A 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- A Disintegrin and Metallopeptidase Domain 1a (ADAM1A)
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别名
- ADAM1
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背景
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Background: Cleaves the membrane-bound precursor of TNF-alpha at \'76-Ala-|-Val-77\' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.
Aliases: A disintegrin and metalloprotease domain 10 antibody, A disintegrin and metalloproteinase domain 10 antibody, AD 10 antibody, AD10 antibody, AD18 antibody, ADA10_HUMAN antibody, ADAM 10 antibody, ADAM metallopeptidase domain 10 antibody, ADAM10 antibody, CD 156c antibody, CD156c antibody, CD156c antigen antibody, CDw156 antibody, disintegrin and metalloproteinase domain containing protein 10 antibody, Disintegrin and metalloproteinase domain-containing protein 10 antibody, HsT 18717 antibody, HsT18717 antibody, Kuz antibody, Kuzbanian antibody, Kuzbanian protein homolog antibody, Kuzbanian, Drosophila, homolog of antibody, MADM antibody, Mammalian disintegrin metalloprotease antibody, Mammalian disintegrin-metalloprotease antibody, RAK antibody
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UniProt
- O14672
抗原
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