DAP Kinase 1 抗体 (AA 1141-1430)
Quick Overview for DAP Kinase 1 抗体 (AA 1141-1430) (ABIN7149553)
抗原
See all DAP Kinase 1 (DAPK1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1141-1430
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Death-associated protein kinase 1 protein (1141-1430AA)
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亚型
- IgG
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anti-Death-Associated Protein Kinase 1 (DAPK1) (AA 1360-1389), (C-Term) antibody
DAPK1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB3033 unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) (AA 1331-1430) antibodyDAPK1 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) (AA 1211-1310) antibodyDAPK1 适用: 人 ELISA, PLA 宿主: 小鼠 Monoclonal 2E7 unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) (Internal Region) antibodyDAPK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) antibodyDAPK1 适用: 人, 小鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) (N-Term) antibodyDAPK1 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) antibodyDAPK1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) (Ser296) antibodyDAPK1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) (AA 1141-1430) antibodyDAPK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) antibodyDAPK1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- DAP Kinase 1 (DAPK1) (Death-Associated Protein Kinase 1 (DAPK1))
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别名
- DAPK1
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背景
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Background: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca2+ influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition. Isoform 2 cannot induce apoptosis but can induce membrane blebbing.
Aliases: DAK1 antibody, DAP K1 antibody, DAP kinase 1 antibody, DAPK 1 antibody, DAPK antibody, DAPK1 antibody, DAPK1_HUMAN antibody, Death Associated Protein Kinase 1 antibody, Death-associated protein kinase 1 antibody, DKFZp781I035 antibody
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UniProt
- P53355
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途径
- MAPK Pathway, Interferon-gamma Pathway
抗原
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