DACT1 抗体 (AA 410-525) (HRP)
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北京 101111
Quick Overview for DACT1 抗体 (AA 410-525) (HRP) (ABIN7149491)
抗原
See all DACT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 410-525
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原理
- DACT1 Antibody, HRP conjugated
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human Dapper homolog 1 protein (410-525AA)
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亚型
- IgG
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anti-Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1) (AA 410-525) antibody
DACT1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1) (AA 725-775) antibodyDACT1 适用: 人, 小鼠, 大鼠, 斑马鱼, 非洲爪蟾, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1) (AA 738-836) antibodyDACT1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5D8 unconjugated
anti-Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1) (AA 13-41), (N-Term) antibodyDACT1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB26834 unconjugated
anti-Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1) (AA 139-188) antibodyDACT1 适用: 人, 小鼠, 大鼠, 斑马鱼, 豚鼠, 兔, 犬, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1) (AA 673-722) antibodyDACT1 适用: 人, 小鼠, 豚鼠, 兔, Bat, 猴, 非洲爪蟾, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1) (AA 343-392) antibodyDACT1 适用: 人, 小鼠, 大鼠, 斑马鱼, Cow, Bat, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- DACT1 (Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1))
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别名
- DACT1
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背景
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Background: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism, the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2, the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.
Aliases: Dact antibody, dact1 antibody, DACT1_HUMAN antibody, Dapper antagonist of beta catenin homolog 1 antibody, Dapper antagonist of catenin 1 antibody, Dapper antibody, Dapper homolog 1 antibody, DAPPER1 antibody, Dpr antibody, Dpr1 antibody, Frd antibody, Frodo antibody, hDPR1 antibody, Hepatocellular carcinoma novel gene 3 protein antibody, Heptacellular carcinoma novel gene 3 antibody, HNG3 antibody, MTNG3 antibody, Thyex3 antibody
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UniProt
- Q9NYF0
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途径
- Positive Regulation of fat Cell Differentiation
抗原
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