CISH 抗体 (AA 1-257)
Quick Overview for CISH 抗体 (AA 1-257) (ABIN7149303)
抗原
See all CISH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-257
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Cytokine-inducible SH2-containing protein (1-257AA)
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亚型
- IgG
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应用备注
- Recommended dilution: IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- CISH (Cytokine Inducible SH2-Containing Protein (CISH))
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别名
- CISH
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背景
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Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Aliases: BACTS2 antibody, cis 1 antibody, CIS antibody, CIS-1 antibody, CIS1 antibody, Cish antibody, CISH_HUMAN antibody, Cytokine inducible inhibitor of signaling type 1B antibody, Cytokine inducible SH2 containing protein antibody, Cytokine-inducible SH2-containing protein antibody, G18 antibody, Protein G18 antibody, SOCS antibody, Suppressor of cytokine signaling antibody
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UniProt
- Q9NSE2
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途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus
抗原
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