CDK7 抗体 (AA 212-341)
Quick Overview for CDK7 抗体 (AA 212-341) (ABIN7148902)
抗原
See all CDK7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 212-341
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Cyclin-dependent kinase 7 protein (212-341AA)
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亚型
- IgG
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anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 1-346) antibody
CDK7 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 1-346) antibodyCDK7 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 1-346) antibodyCDK7 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (C-Term) antibodyCDK7 适用: 人, 小鼠, 大鼠, Cow, 马, Pig, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 211-346) antibodyCDK7 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (pThr170) antibodyCDK7 适用: 人, 小鼠 WB, IHC (p), DB 宿主: 兔 Polyclonal RB07518 unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (C-Term) antibodyCDK7 适用: 人, 小鼠, 大鼠, Cow, 马, Pig, 犬, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 1-80) antibodyCDK7 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (C-Term) antibodyCDK7 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 1-130) antibodyCDK7 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- CDK7 (Cyclin-Dependent Kinase 7 (CDK7))
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别名
- CDK7
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背景
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Background: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53, this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
Aliases: 39 kDa protein kinase antibody, CAK antibody, CAK1 antibody, Cdk activating kinase antibody, CDK-activating kinase 1 antibody, CDK-activating kinase antibody, cdk7 antibody, CDK7_HUMAN antibody, CDKN7 antibody, Cell division protein kinase 7 antibody, Cyclin dependent kinase 7 antibody, cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) antibody, Cyclin-dependent kinase 7 antibody, HCAK antibody, Homolog of Xenopus MO15 Cdk activating kinase antibody, Kinase subunit of CAK antibody, MO15 antibody, MO15, Xenopus, homolog of antibody, P39 Mo15 antibody, p39MO15 antibody, Serine threonine kinase Stk1 antibody, Serine/threonine protein kinase 1 antibody, Serine/threonine protein kinase MO15 antibody, STK1 antibody, TFIIH basal transcription factor complex kinase subunit antibody
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UniProt
- P50613
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途径
- Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, M Phase
抗原
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