CRTC1 抗体 (AA 1-248) (Biotin)
Quick Overview for CRTC1 抗体 (AA 1-248) (Biotin) (ABIN7148676)
抗原
See all CRTC1 抗体适用
宿主
克隆类型
标记
应用范围
- 
    
- 
                                            
抗原表位
 - AA 1-248
 - 
                                            
交叉反应
 - 人
 - 
                                            
纯化方法
 - >95%, Protein G purified
 - 
                                            
免疫原
 - Recombinant Human CREB-regulated transcription coactivator 1 protein (1-248AA)
 - 
                                            
亚型
 - IgG
 
 - 
                                            
 - 
    
 - 
    
- 
                                            
应用备注
 - Optimal working dilution should be determined by the investigator.
 - 
                                            
限制
 - 仅限研究用
 
 - 
                                            
 - 
    
- 
                                            
状态
 - Liquid
 - 
                                            
缓冲液
 - 
                        Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 
                                            
储存液
 - ProClin
 - 
                                            
注意事项
 - This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
 - 
                                            
储存条件
 - -20 °C,-80 °C
 - 
                                            
储存方法
 - Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
 
 - 
                                            
 - 
    
- CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))
 - 
                                            
别名
 - CRTC1
 - 
                                            
背景
 - 
                        
Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 \'Ser-133\' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
Aliases: KIAA0616 antibody, CREB regulated transcription coactivator 1 antibody, CREB-regulated transcription coactivator 1 antibody, CRTC1 antibody, CRTC1_HUMAN antibody, FLJ14027 antibody, MECT 1 antibody, Mucoepidermoid carcinoma translocated 1 antibody, Mucoepidermoid carcinoma translocated protein 1 antibody, TORC-1 antibody, TORC1 antibody, Transducer of CREB protein 1 antibody, Transducer of regulated cAMP response element binding protein 1 antibody, Transducer of regulated cAMP response element-binding protein (CREB) 1 antibody, Transducer of regulated cAMP response element-binding protein 1 antibody, WAMTP1 antibody
 - 
                                            
UniProt
 - Q6UUV9
 
抗原
 -