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- 抗原 See all MCC 抗体
- MCC (Mutated in Colorectal Cancers (MCC))
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抗原表位
- AA 479-611
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MCC antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Colorectal mutant cancer protein (479-611AA)
- 亚型
- IgG
- Top Product
- Discover our top product MCC Primary Antibody
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anti-Mutated in Colorectal Cancers (MCC) (AA 1-829) antibody
MCC 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 31-130) antibodyMCC 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 1A7 unconjugated
anti-Mutated in Colorectal Cancers (MCC) (Center) antibodyMCC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 31-130) antibodyMCC 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Mutated in Colorectal Cancers (MCC) (AA 1-829) antibodyMCC 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- MCC (Mutated in Colorectal Cancers (MCC))
- 别名
- MCC (MCC 产品)
- 背景
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Background: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).
Aliases: Colorectal mutant cancer protein antibody, CRCM_HUMAN antibody, DKFZp762O1615 antibody, FLJ38893 antibody, FLJ46755 antibody, MCC 1 antibody, MCC antibody, MCC1 antibody, Mutated in colorectal cancers antibody, Protein MCC antibody
- UniProt
- P23508
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