Clusterin 抗体 (AA 23-224)
Quick Overview for Clusterin 抗体 (AA 23-224) (ABIN7147944)
抗原
See all Clusterin (CLU) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 23-224
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Clusterin protein (23-224AA)
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亚型
- IgG
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anti-Clusterin (CLU) (AA 331-449) antibody
CLU 适用: 人, 大鼠, 小鼠 ELISA, IHC (p), FACS, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 229-446) antibodyCLU 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 227-448) antibodyCLU 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 228-449) antibodyCLU 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 226-447) antibodyCLU 适用: 兔 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C10 unconjugated
anti-Clusterin (CLU) (C-Term) antibodyVerified CLU 适用: 人 WB, IHC, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 23-120) antibodyCLU 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Clusterin (CLU) (AA 227-447) antibodyCLU 适用: 大鼠 WB, IHC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Clusterin (CLU) (AA 402-501) antibodyCLU 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A11 unconjugated
anti-Clusterin (CLU) (Internal Region) antibodyCLU 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Clusterin (CLU)
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别名
- CLU
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背景
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Background: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
Aliases: 40 antibody, AAG 4 antibody, AAG4 antibody, Aging associated protein 4 antibody, Aging-associated gene 4 protein antibody, AI893575 antibody, APO J antibody, Apo-J antibody, APOJ antibody, ApoJalpha antibody, ApoJbeta antibody, Apolipoprotein J antibody, ApolipoproteinJ antibody, CLI antibody, CLU antibody, CLU1 antibody, CLU2 antibody, CLUS_HUMAN antibody, Clusterin alpha chain antibody, Clusterin antibody, Clusterin beta chain antibody, Complement associated protein SP 40 40 antibody, Complement associated protein SP 40 antibody, Complement associated protein SP40 antibody, Complement cytolysis inhibitor a chain antibody, Complement cytolysis inhibitor antibody, Complement cytolysis inhibitor b chain antibody, Complement lysis inhibitor antibody, Complement-associated protein SP-40 antibody, D14Ucla3 antibody, Dimeric acid glycoprotein antibody, Glycoprotein 80 antibody, Glycoprotein III antibody, GP80 antibody, Ku70-binding protein 1 antibody, KUB 1 antibody, KUB1 antibody, MGC24903 antibody, NA1/NA2 antibody, RATTRPM2B antibody, SGP 2 antibody, SGP2 antibody, SP 40 antibody, SP40 antibody, Sugp-2 antibody, Sulfated glycoprotein 2 antibody, Testosterone repressed prostate message 2 antibody, Testosterone-repressed prostate message 2 antibody, TRPM 2 antibody, TRPM-2 antibody, TRPM2 antibody, TRPM2B antibody, Trpmb antibody
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UniProt
- P10909
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途径
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
抗原
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