BHLHE41 抗体 (AA 185-285)
Quick Overview for BHLHE41 抗体 (AA 185-285) (ABIN7147841)
抗原
See all BHLHE41 抗体适用
宿主
克隆类型
标记
应用范围
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                                            抗原表位
- AA 185-285
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                                            交叉反应
- 人
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                                            纯化方法
- >95%, Protein G purified
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                                            免疫原
- Recombinant Human Class E basic helix-loop-helix protein 41 protein (185-285AA)
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                                            亚型
- IgG
 
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                                            应用备注
- Recommended dilution: WB:1:500-1:5000,
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                                            限制
- 仅限研究用
 
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                                            状态
- Liquid
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                                            缓冲液
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                        Preservative: 0.03 % Proclin 300
 Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
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                                            储存液
- ProClin
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                                            注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            储存条件
- -20 °C,-80 °C
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                                            储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
 
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    - BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))
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                                            别名
- BHLHE41
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                                            背景
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                        Background: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5\\\'-CACGTG-3\\\') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Aliases: Basic helix-loop-helix domain containing class B3 antibody, BHE41_HUMAN antibody, bHLH protein DEC2 antibody, bHLHB3 antibody, bHLHe41 antibody, Class B basic helix loop helix protein 3 antibody, Class B basic helix-loop-helix protein 3 antibody, Class E basic helix-loop-helix protein 41 antibody, DEC2 antibody, Differentially expressed in chondrocytes protein 2 antibody, Enhancer of split and hairy related protein 1 antibody, Enhancer-of-split and hairy-related protein 1 antibody, hDEC2 antibody, Moderately similar to basic-helix loop helix protein M.musculus antibody, SHARP-1 antibody 
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                                            UniProt
- Q9C0J9
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                                            途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
 抗原
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