MAPKAP Kinase 2 抗体 (pSer272) (Cy5)
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Quick Overview for MAPKAP Kinase 2 抗体 (pSer272) (Cy5) (ABIN710535)
抗原
See all MAPKAP Kinase 2 (MAPKAPK2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer272
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原理
- Phospho-MAPKAPK2 (Ser272) Polyclonal Antibody, Cy5 Conjugated
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交叉反应
- Cow, 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human MAPKAPK2 around the phosphorylation site of Ser272
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亚型
- IgG
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应用备注
- WB(1:300-5000), IF(1:50-200)
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- MAPKAP Kinase 2 (MAPKAPK2) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2))
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别名
- MAPKAPK2
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背景
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Synonyms: MAPKAPK2phospho S272,P-MAPKAPK2Ser272, MAP Kinase Activated Protein Kinase 2, MAPK activated protein kinase 2, MAPKAP kinase 2, MAPKAPK 2, MAPKAPK2, Mitogen Activated Protein Kinase Activated Protein Kinase 2, MAPK2_HUMAN, MK 2, MK2, MAPKAPK-2.
Background: MAP kinase activated protein kinase 2 (MAPKAP Kinase 2), also known as p45 hsp27 kinase, is a 45-54 kDa serine/threonine protein kinase that contains a proline rich sequence and two putative SH3 binding sites. MAPKAP Kinase 2 is activated in response to stress, IL1 and TNF, possibly catalyzed by p38/Hog dependent phosphorylation. One of the major substrates of MAPKAP Kinase 2 is hsp27, which stimulates actin polymerization in order to facilitate recovery from destruction of cytoskeleton during cellular stresses. MAPKAP2 is implicated in several disorders including ischemic brain injury and heart failure and has been shown to be important in regulating stress resistance and the production of TNF alpha.
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分子量
- 44kDa
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基因ID
- 9261
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途径
- MAPK Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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