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CETN2 抗体 (AA 1-172) (FITC)

CETN2 适用: 人 宿主: 兔 Polyclonal FITC
产品编号 ABIN7147355
发货至: 中国
  • 抗原 See all CETN2 抗体
    CETN2 (Centrin, EF-Hand Protein, 2 (CETN2))
    抗原表位
    • 15
    • 8
    • 2
    • 1
    • 1
    AA 1-172
    适用
    • 31
    • 19
    • 4
    宿主
    • 26
    • 5
    克隆类型
    • 30
    • 1
    多克隆
    标记
    • 13
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CETN2 antibody is conjugated to FITC
    应用范围
    请咨询
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Centrin-2 protein (1-172AA)
    亚型
    IgG
    Top Product
    Discover our top product CETN2 Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    CETN2 (Centrin, EF-Hand Protein, 2 (CETN2))
    别名
    CETN2 (CETN2 产品)
    别名
    cb732 antibody, CETN2 antibody, 1110034A02Rik antibody, AI326150 antibody, Calt antibody, caltractin antibody, CALT antibody, CEN2 antibody, caltractin antibody, centrin 2 antibody, centrin 4 antibody, LOC412449 antibody, CETN2 antibody, cetn4 antibody, Cetn2 antibody
    背景

    Background: Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.RInvolved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5\'-to-3\' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.

    Aliases: 20kD calcium binding protein antibody, CALT antibody, caltractin antibody, Caltractin isoform 1 antibody, CEN2 antibody, centrin antibody, centrin, EF hand protein, 2 antibody, Centrin-2 antibody, Centrin2 antibody, CETN2 antibody, CETN2_HUMAN antibody, EF hand protein 2 antibody, EF-hand protein antibody

    UniProt
    P41208
    途径
    DNA Damage Repair, M Phase
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