CTNNA1 抗体 (AA 1-288)
Quick Overview for CTNNA1 抗体 (AA 1-288) (ABIN7146972)
抗原
See all CTNNA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-288
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Catenin alpha-1 protein (1-288AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:1000-1:2000, IF:1:200-1:500,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))
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别名
- CTNNA1
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背景
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Background: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Aliases: Alpha E-catenin antibody, Cadherin associated protein 102 kDa antibody, Cadherin associated protein antibody, Cadherin-associated protein antibody, CAP 102 antibody, CAP102 antibody, Catenin (cadherin associated protein) alpha 1 102 kDa antibody, Catenin (cadherin associated protein), alpha 1, 102 kDa antibody, Catenin alpha 1 antibody, Catenin alpha-1 antibody, CTNA1_HUMAN antibody, CTNNA 1 antibody, Ctnna1 antibody, FLJ36832 antibody, FLJ52416 antibody, MDPT2 antibody, NY REN 13 antigen antibody, OTTHUMP00000224141 antibody, OTTHUMP00000224147 antibody, Renal carcinoma antigen NY REN 13 antibody, Renal carcinoma antigen NY-REN-13 antibody
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UniProt
- P35221
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途径
- Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location
抗原
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