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BBS5 抗体 (AA 224-317)

BBS5 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7145242
发货至: 中国
  • 抗原 See all BBS5 抗体
    BBS5 (Bardet-Biedl Syndrome 5 (BBS5))
    抗原表位
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 224-317
    适用
    • 14
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 11
    • 3
    克隆类型
    • 13
    • 1
    多克隆
    标记
    • 11
    • 1
    • 1
    • 1
    This BBS5 antibody is un-conjugated
    应用范围
    • 11
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Bardet-Biedl syndrome 5 protein (224-317AA)
    亚型
    IgG
    Top Product
    Discover our top product BBS5 Primary Antibody
  • 应用备注
    Recommended dilution: IHC:1:200-1:500,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    BBS5 (Bardet-Biedl Syndrome 5 (BBS5))
    别名
    BBS5 (BBS5 产品)
    别名
    zgc:56578 antibody, 1700049I01Rik antibody, 2700023J09Rik antibody, Bardet-Biedl syndrome 5 antibody, Bardet-Biedl syndrome 5 (human) antibody, bbs5 antibody, BBS5 antibody, Bbs5 antibody
    背景

    Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.

    Aliases: Bardet Biedl syndrome 5 protein antibody, Bardet-Biedl syndrome 5 protein antibody, BBS5 antibody, BBS5_HUMAN antibody

    UniProt
    Q8N3I7
    途径
    Hedgehog Signaling
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