DARC 抗体 (AA 1-63) (HRP)
Quick Overview for DARC 抗体 (AA 1-63) (HRP) (ABIN7145069)
抗原
See all DARC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-63
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Atypical chemokine receptor 1 protein (1-63AA)
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亚型
- IgG
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anti-Duffy Blood Group, Chemokine Receptor (DARC) (N-Term) antibody
Verified DARC 适用: 人 WB, ELISA, IHC, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Duffy Blood Group, Chemokine Receptor (DARC) (AA 1-336) antibodyDARC 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Duffy Blood Group, Chemokine Receptor (DARC) (AA 71-330) antibodyDARC 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Duffy Blood Group, Chemokine Receptor (DARC) (AA 1-63) antibodyDARC 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Duffy Blood Group, Chemokine Receptor (DARC) (AA 1-30), (N-Term) antibodyDARC 适用: 人 WB 宿主: 兔 Polyclonal RB42735 unconjugated
anti-Duffy Blood Group, Chemokine Receptor (DARC) antibodyDARC 适用: 人 ELISA, FACS, BP 宿主: 兔 Chimeric 2C3 unconjugated Recombinant Antibody
anti-Duffy Blood Group, Chemokine Receptor (DARC) (N-Term) antibody (Biotin)Verified DARC 适用: 人 WB, ELISA, IHC, FACS 宿主: 山羊 Polyclonal Biotin
anti-Duffy Blood Group, Chemokine Receptor (DARC) (AA 1-50) antibodyDARC 适用: 人 ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Duffy Blood Group, Chemokine Receptor (DARC) (AA 1-336) antibodyDARC 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Duffy Blood Group, Chemokine Receptor (DARC) antibody (PE)DARC 适用: 人 IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal PE
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- DARC (Duffy Blood Group, Chemokine Receptor (DARC))
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别名
- ACKR1
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背景
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Background: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes, when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Aliases: ACKR1 antibody, Atypical chemokine receptor 1 antibody, CCBP1 antibody, CD234 antibody, DARC antibody, Dfy antibody, Duffy antigen/chemokine receptor antibody, duffy blood group antibody, Duffy blood group antigen antibody, Duffy blood group chemokine receptor antibody, DUFFY_HUMAN antibody, FY antibody, Fy glycoprotein antibody, Glycoprotein D antibody, GPD antibody, GpFy antibody, Plasmodium vivax receptor antibody, WBCQ1 antibody
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UniProt
- Q16570
抗原
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