ARF1 抗体 (AA 2-181) (HRP)
Quick Overview for ARF1 抗体 (AA 2-181) (HRP) (ABIN7143445)
抗原
See all ARF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-181
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human ADP-ribosylation factor 1 protein (2-181AA)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- ARF1 (ADP-Ribosylation Factor 1 (ARF1))
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别名
- ARF1
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背景
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Background: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity, the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
Aliases: ADP Ribosylation Factor 1 antibody, ADP-ribosylation factor 1 antibody, ARF 1 antibody, ARF1 antibody, ARF1_HUMAN antibody
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UniProt
- P84077
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途径
- Transition Metal Ion Homeostasis, Inositol Metabolic Process
抗原
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