Serotonin Receptor 2B 抗体 (AA 382-481)
Quick Overview for Serotonin Receptor 2B 抗体 (AA 382-481) (ABIN7142626)
抗原
See all Serotonin Receptor 2B (HTR2B) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 382-481
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human 5-hydroxytryptamine receptor 2B protein (382-481AA)
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亚型
- IgG
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应用备注
- Recommended dilution: IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Serotonin Receptor 2B (HTR2B)
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别名
- HTR2B
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背景
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Background: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.
Aliases: 5 HT 2B antibody, 5 HT 2B receptor antibody, 5 HT(2B) antibody, 5 HT2B antibody, 5 hydroxytryptamine (serotonin) receptor 2B antibody, 5 hydroxytryptamine (serotonin) receptor 2B G protein coupled antibody, 5 hydroxytryptamine 2B receptor antibody, 5 hydroxytryptamine receptor 2B antibody, 5-HT-2B antibody, 5-HT2B antibody, 5-hydroxytryptamine receptor 2B antibody, 5HT(2B) antibody, 5HT2B Receptor antibody, 5HT2B_HUMAN antibody, 5HT2F antibody, Htr 2b antibody, Htr2b antibody, NP75 protein antibody, SEROTONIN 5HT2B RECEPTOR antibody, Serotonin receptor 2B antibody, Stomach fundus serotonin receptor antibody
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UniProt
- P41595
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途径
- JAK/STAT Signaling, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process
抗原
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