Serotonin Receptor 2B 抗体 (Extracellular, N-Term)
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Quick Overview for Serotonin Receptor 2B 抗体 (Extracellular, N-Term) (ABIN7043619)
抗原
See all Serotonin Receptor 2B (HTR2B) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 6-20, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 2B
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical,human - 11,15 amino acid residues identical
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产品特性
- Anti-5HT2B Receptor (HTR2B) (extracellular) Antibody (ABIN7043619, ABIN7045288 and ABIN7045289) is a highly specific antibody directed against an epitope of the rat 5-B receptor. The antibody can be used in western blot and immunohistochemistry applications. It recognizes an extracellular epitope and can potentially detect 5HT2B receptor in living cells. It has been designed to recognize 5-hydroxytryptamine receptor 2B from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KMSEQ STISEHILQK, corresponding to amino acid residues 6-20 of rat 5-Hydroxytryptamine receptor 2B
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亚型
- IgG
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anti-Serotonin Receptor 2B (HTR2B) (Internal Region) antibody
HTR2B 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 2B (HTR2B) (AA 408-435), (C-Term) antibodyHTR2B 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB20470 unconjugated
anti-Serotonin Receptor 2B (HTR2B) (N-Term) antibodyHTR2B 适用: 人, Cow, 犬, 豚鼠, Pig, 马 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 2B (HTR2B) (AA 382-481) antibodyHTR2B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 2B (HTR2B) (AA 1-56) antibodyHTR2B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Serotonin Receptor 2B (HTR2B) (AA 382-481) antibodyHTR2B 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 2B (HTR2B) (AA 261-310) antibodyHTR2B 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 2B (HTR2B) (AA 1-481) antibodyHTR2B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 2B (HTR2B) (AA 1-56) antibodyHTR2B 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4A4 unconjugated
anti-Serotonin Receptor 2B (HTR2B) (AA 15-64) antibodyHTR2B 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 mg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:400
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236792)
Blocking Peptide: (ABIN7236792)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Serotonin Receptor 2B (HTR2B)
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别名
- HTR2B
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背景
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Synonyms: 5-Hydroxytryptamine receptor 2B, Serotonin receptor 2B, 5-HT-2B, 5-HT2F, Stomach fundus serotonin receptor
Description: 5-HT is involved in a variety of physiological and biological processes. In the brain, 5-HT has been found to affect sleep, mood, appetite, anxiety, aggression, perception, pain, and cognition1. Signaling of 5-HT is mediated by receptors that are located on the cell membrane of neurons and most other cells in the body. The 5-HT2 family consists of three G-protein coupled receptors (GPCRs): 5-HT2A, 5-HT2B, and 5-HT2C2. Like other members, they are transmembrane proteins consisting of seven membrane-spanning α-helical segments with an extracellular N-terminus and an intracellular C-terminus. The binding of 5-HT to one of its receptors is thought to elicit a conformational change that activates associated heterotrimeric G proteins and recruits other downstream signaling/scaffolding molecules, such as GPCR kinases and β-arrestins.5-HT2B receptors have been found to be present in both rodent and human tissues, particularly in the cardiovascular system, gastrointestinal tract, bone, and central nervous system2. Only low expression levels are found in the brain and blood. The highest expression levels are found in the stomach fundus3.Over-expression of 5-HT2B receptors in hearts of transgenic mice results in cardiac hypertrophy and decreased ventricular function due to enhanced extracellular matrix (ECM) and remodeling. Likewise, genetic deletion of 5-HT2B receptors was shown to lead to ventricular dilation and incomplete cardiac development5.
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基因ID
- 29581
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NCBI登录号
- NM_000867
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UniProt
- P30994
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途径
- JAK/STAT Signaling, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process
抗原
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