Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2) (AA 1-147) 抗体 (Biotin)
Quick Overview for Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2) (AA 1-147) 抗体 (Biotin) (ABIN7141317)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-147
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Virus Strain
- strain B95-8
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原理
- LMP2 Antibody, Biotin conjugated
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交叉反应
- Epstein-Barr Virus (EBV)
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA)
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亚型
- IgG
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anti-Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2) (AA 401-497) antibody
EBV LMP2 适用: 人, Virus IF (cc), IF (p), ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2)
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别名
- Epstein-Barr virus (strain B95-8) (HHV-4) (Herpex simplex 4) LMP2
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背景
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Background: Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.
Aliases: LMP2 antibody, Latent membrane protein 2 antibody, Terminal protein antibody
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UniProt
- P13285
抗原
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