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HMGB1 抗体 (AA 2-18)

This anti-HMGB1 antibody is a 兔 多克隆 antibody detecting HMGB1 in WB 和 ELISA. Suitable for 大鼠.
产品编号 ABIN7140251
发货至: 中国

Quick Overview for HMGB1 抗体 (AA 2-18) (ABIN7140251)

抗原

See all HMGB1 抗体
HMGB1 (High Mobility Group Box 1 (HMGB1))

适用

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大鼠

宿主

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  • 45
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  • 1

克隆类型

  • 143
  • 65
多克隆

标记

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This HMGB1 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA
  • 抗原表位

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    AA 2-18

    交叉反应

    大鼠

    纯化方法

    >95%, Antigen Affinity purified & Affinity purified

    免疫原

    Peptide sequence from Rat Hmgb1 protein (2-18AA)

    亚型

    IgG
  • 应用备注

    Recommended dilution: WB:1:1000-1:5000,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    HMGB1 (High Mobility Group Box 1 (HMGB1))

    别名

    Hmgb1

    背景

    Background: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide (PubMed:11154118). Bound to RAGE mediates signaling for neuronal outgrowth (PubMed:1885601, PubMed:2461949, PubMed:7592757, PubMed:12183440). May play a role in accumulation of expanded polyglutamine (polyQ) proteins.

    Aliases: Hmgb1 antibody, Hmg-1 antibody, Hmg1 antibody, High mobility group protein B1 antibody, Amphoterin antibody, Heparin-binding protein p30 antibody, High mobility group protein 1 antibody, HMG-1 antibody

    UniProt

    P63159

    途径

    p53 Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome
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