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ROCK2 抗体 (pTyr722)

This anti-ROCK2 antibody (ABIN7139057) is a Rabbit Polyclonal antibody detecting ROCK2 in WB, ELISA. Suitable for Human.
产品编号 ABIN7139057
发货至: 中国

Quick Overview for ROCK2 抗体 (pTyr722) (ABIN7139057)

抗原

See all ROCK2 抗体
ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

适用

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宿主

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克隆类型

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多克隆

标记

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This ROCK2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA
  • 抗原表位

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    pTyr722

    交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

    免疫原

    Peptide sequence around phosphorylation site of Tyrosine 722(K-I-Y(p)-E-S) derived from Human ROCK2.

    亚型

    IgG
  • 应用备注

    WB:1:500-1:1000,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

    别名

    ROCK2

    背景

    Background: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus.

    Aliases: coiled-coil-containing protein kinase 2 antibody, KIAA0619 antibody, p164 ROCK 2 antibody, p164 ROCK-2 antibody, Rho associated coiled coil containing protein kinase 2 antibody, Rho associated protein kinase 2 antibody, Rho associated, coiled coil containing protein kinase II antibody, Rho kinase 2 antibody, Rho-associated antibody, Rho-associated protein kinase 2 antibody, ROCK 2 antibody, Rock II antibody, Rock2 antibody, ROCK2_HUMAN antibody, Rock2m antibody, ROK alpha antibody, ROKalpha antibody

    UniProt

    O75116

    途径

    Microtubule Dynamics, WNT signaling, Tube Formation
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