SP1 抗体 (pThr739)
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- 抗原 See all SP1 抗体
- SP1 (Sp1 Transcription Factor (SP1))
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抗原表位
- pThr739
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人, 大鼠
- 纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- 免疫原
- Peptide sequence around phosphorylation site of threonine 739 (T-A-T(p)-P-S) derived from Human SP1
- 亚型
- IgG
- Top Product
- Discover our top product SP1 Primary Antibody
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- 应用备注
- WB:1:500-1:1000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- SP1 (Sp1 Transcription Factor (SP1))
- 别名
- SP1 (SP1 产品)
- 背景
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Background: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-a G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
Thiesen HJ,et al.(1990)Nucleic Acids Res.18(11):3203-9.
Zutter MM,et al.(1997) Blood.90(2):678-89.
Lou Z,et al.(2005)Cancer Res.65(3):1007-17Aliases: SP 1 antibody, SP1 antibody, Sp1 transcription factor antibody, SP1_HUMAN antibody, Specificity protein 1 antibody, Transcription factor Sp1 antibody, TSFP 1 antibody, TSFP1 antibody
- UniProt
- P08047
- 途径
- Regulation of Lipid Metabolism by PPARalpha, Myometrial Relaxation and Contraction
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