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SP1 抗体 (pThr739)

SP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6255733
发货至: 中国
  • 抗原 See all SP1 抗体
    SP1 (Sp1 Transcription Factor (SP1))
    抗原表位
    • 20
    • 14
    • 11
    • 7
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
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    • 2
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    • 1
    • 1
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    pThr739
    适用
    • 95
    • 63
    • 42
    • 10
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
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    人, 小鼠, 大鼠
    宿主
    • 96
    • 13
    • 3
    克隆类型
    • 89
    • 23
    多克隆
    标记
    • 67
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
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    This SP1 antibody is un-conjugated
    应用范围
    • 90
    • 46
    • 45
    • 37
    • 22
    • 16
    • 14
    • 13
    • 13
    • 8
    • 4
    • 3
    • 3
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    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Phospho-SP1 (Thr739) Antibody detects endogenous levels of SP1 only when phosphorylated at Threonine 739.
    预测反应
    Pig,Bovine,Sheep,Rabbit,Dog,Chicken
    纯化方法
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    免疫原
    A synthesized peptide derived from human SP1 around the phosphorylation site of Thr739.
    亚型
    IgG
    Top Product
    Discover our top product SP1 Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    SP1 (Sp1 Transcription Factor (SP1))
    别名
    SP1 (SP1 产品)
    别名
    fc18h09 antibody, zgc:85950 antibody, wu:fc18h09 antibody, SP1 antibody, 1110003E12Rik antibody, AA450830 antibody, AI845540 antibody, Sp1-1 antibody, sp1 transcription factor antibody, Sp1 transcription factor antibody, Sp1 transcription factor L homeolog antibody, trans-acting transcription factor 1 antibody, sp1 antibody, SP1 antibody, Sp1 antibody, sp1.L antibody
    背景

    Description: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).

    Gene: SP1

    分子量
    81kDa
    基因ID
    6667
    UniProt
    P08047
    途径
    Regulation of Lipid Metabolism by PPARalpha, Myometrial Relaxation and Contraction
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