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PKC beta 抗体 (pThr641)

Name: PKC beta 抗体 (pThr641)
Brand: antibodies-online
SKU: ABIN7138871
Availability: OutOfStock

This anti-PKC beta antibody is a 兔多克隆 antibody detecting PKC beta in WB, ELISA, IHC 和 IF. Suitable for 人.

Western blot analysis of extracts from JK cells untreated or treated with PMA using PKCβ (phospho-Thr641) antibody. (PKC beta 抗体 (pThr641))

Immunofluorescence staining of methanol-fixed MCF7 cells using PKCb(phospho-Thr641) antibody. (PKC beta 抗体 (pThr641))

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using PKCb(phospho-Thr641) antibody. (PKC beta 抗体 (pThr641))

IHC

3 images

产品编号 ABIN7138871

发货至: 中国

Quick Overview for PKC beta 抗体 (pThr641) (ABIN7138871)

抗原

See all PKC beta (PRKCB) 抗体

PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))

适用

人

宿主

兔

克隆类型

多克隆

标记

This PKC beta antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Discover our top product PRKCB Primary Antibody

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pThr641

交叉反应

人, 小鼠, 大鼠

纯化方法

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

免疫原

Peptide sequence around phosphorylation site of threonine 641 (E-L-T(p)-P-T) derived from Human PKCb

亚型

IgG
anti-Protein Kinase C, beta (PRKCB) (AA 1-270) antibody
PRKCB 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (AA 220-340) antibody
PRKCB 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (pThr500) antibody
PRKCB 适用: 人, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (AA 517-643) antibody
PRKCB 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (Internal Region) antibody
Verified PRKCB 适用: 人, 大鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (AA 642-673) antibody
PRKCB 适用: 人, 大鼠, 小鼠, 灵长类 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (AA 601-673) antibody
PRKCB 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (AA 261-341) antibody
PRKCB 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (AA 1-671) antibody
PRKCB 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (C-Term) antibody
PRKCB 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

限制

仅限研究用
状态

Liquid

缓冲液

Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))

别名

PRKCB

背景

Background: Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652', leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters. Zhang Y, et al. (2006) Mol Cell Biol , 26: 6748-6761 Castoria G, et al. (2004) Mol Cell Biol , 24: 7643-7653 Marcil J, et al. (1999) Biochem J , 337:185-192 Bornancin F, et al. (1996) Curr Biol , 6:1114-1123.
Aliases: KPCB_HUMAN antibody, PKC Beta antibody, PKC-B antibody, PKC-beta antibody, PKCB antibody, Prkcb antibody, PRKCB II antibody, PRKCB2 antibody, Protein kinase C beta antibody, Protein kinase C beta type antibody

UniProt

P05771

途径

WNT signaling, TCR Signaling, Thyroid Hormone Synthesis, Nuclear Hormone Receptor Binding, Chromatin Binding, Myometrial Relaxation and Contraction, VEGF Signaling, Unfolded Protein Response, BCR Signaling