STK4 抗体 (pThr183)
Quick Overview for STK4 抗体 (pThr183) (ABIN7138786)
抗原
See all STK4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr183
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交叉反应
- 人, 小鼠
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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免疫原
- Peptide sequence around phosphorylation site of threonine 183 (R-N-T(p)-V-I) derived from Human Mst1/2.
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亚型
- IgG
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anti-serine/threonine Kinase 4 (STK4) (AA 391-485) antibody
STK4 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 4F4 unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 1-39) antibodySTK4 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1D7-8A10 unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 303-487) antibodySTK4 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (C-Term) antibodyKO Validated STK4 适用: 人 WB, IP, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 391-485) antibodySTK4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) antibodySTK4 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 385-415) antibodySTK4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 6-24) antibodySTK4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (C-Term) antibodySTK4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) antibodySTK4 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB:1:500-1:3000, IHC:1:50-1:100,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- STK4 (serine/threonine Kinase 4 (STK4))
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别名
- STK4
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背景
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Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation By similarity.
Aliases: Kinase responsive to stress antibody, Krs2 antibody, Mammalian STE20 like protein kinase 1 antibody, Mammalian STE20-like protein kinase 1 antibody, Mammalian sterile 20 like 1 antibody, MST-1 antibody, MST1 antibody, Serine/threonine kinase 4 antibody, Serine/threonine protein kinase Krs 2 antibody, Serine/threonine-protein kinase 4 antibody, Serine/threonine-protein kinase Krs-2 antibody, STE20 like kinase MST1 antibody, STE20-like kinase MST1 antibody, STK4 antibody, STK4_HUMAN antibody, TIIAC antibody, YSK3 antibody
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UniProt
- Q13043
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途径
- Tube Formation
抗原
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