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- 抗原 See all STK4 抗体
- STK4 (serine/threonine Kinase 4 (STK4))
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抗原表位
- C-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This STK4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 特异性
- MST-1/STK4 Antibody detects endogenous levels of total MST-1/STK4.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human STK4, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product STK4 Primary Antibody
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anti-serine/threonine Kinase 4 (STK4) (AA 391-485) antibody
STK4 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 4F4 unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 1-39) antibodySTK4 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1D7-8A10 unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 303-487) antibodySTK4 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (C-Term) antibodyKO Validated STK4 适用: 人 WB, IP, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) antibodySTK4 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 391-485) antibodySTK4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 385-415) antibodySTK4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) antibodySTK4 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 6-24) antibodySTK4 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (pThr183) antibodySTK4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- STK4 (serine/threonine Kinase 4 (STK4))
- 别名
- STK4 (STK4 产品)
- 别名
- KRS2 antibody, MST1 antibody, TIIAC antibody, YSK3 antibody, AI447339 antibody, AU020804 antibody, Kas-2 antibody, Mst1 antibody, Ysk3 antibody, krs2 antibody, mst1 antibody, ysk3 antibody, serine/threonine kinase 4 antibody, serine/threonine kinase 4 S homeolog antibody, STK4 antibody, Stk4 antibody, stk4.S antibody
- 背景
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Description: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
Gene: STK4
- 分子量
- 56 kDa
- 基因ID
- 6789
- UniProt
- Q13043
- 途径
- Tube Formation
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