HDAC4 抗体 (pSer220, pSer246, pSer259)
Quick Overview for HDAC4 抗体 (pSer220, pSer246, pSer259) (ABIN7138509)
抗原
See all HDAC4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer220, pSer246, pSer259
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原理
- Phospho-HDAC4/HDAC5/HDAC9 (Ser246/259/220) Antibody
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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免疫原
- Peptide sequence around phosphorylation site of serine 246/259/220 (T-A-S(p)-EP) derived from Human HDAC4/HDAC5/HDAC9.
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亚型
- IgG
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anti-Histone Deacetylase 4 (HDAC4) (AA 904-1076) antibody
HDAC4 适用: 小鼠 WB, IHC, IP, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 4 (HDAC4) (AA 551-648) antibodyHDAC4 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-Histone Deacetylase 4 (HDAC4) (AA 456-592) antibodyHDAC4 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 7E2E6 unconjugated
anti-Histone Deacetylase 4 (HDAC4) (AA 456-592) antibodyHDAC4 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 5E4A5 unconjugated
anti-Histone Deacetylase 4 (HDAC4) (AA 451-650) antibodyHDAC4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 4 (HDAC4) (AA 1049-1077) antibodyHDAC4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 4 (HDAC4) (AA 530-630) antibodyHDAC4 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 4 (HDAC4) antibodyHDAC4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 4 (HDAC4) antibodyHDAC4 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 4 (HDAC4) (pSer632) antibodyHDAC4 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- HDAC4 (Histone Deacetylase 4 (HDAC4))
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别名
- HDAC4
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背景
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Background:
Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general,they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs, classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.
Cress, W.D. and Seto, E. (2000) J Cell Physiol 184, 1-16.
Vigushin, D.M. and Coombes, R.C. (2004) Curr. Cancer Drug Targets 4, 205-218.
Marmorstein, R. (2001) Cell Mol Life Sci 58, 693-703.
Thiagalingam, S. et al. (2003) Ann. N.Y. Acad. Sci. 983, 84-100.Aliases: HD4/HD5/HD9
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UniProt
- P56524, Q9UQL6, Q9UKV0
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process
抗原
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