SNAIL 抗体 (pSer246)
Quick Overview for SNAIL 抗体 (pSer246) (ABIN7138508)
抗原
See all SNAIL (SNAI1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer246
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交叉反应
- 人, 小鼠
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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免疫原
- Peptide sequence around phosphorylation site of Serine 246(T-F-S(p)-R-M) derived from Human SNAI1.
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亚型
- IgG
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anti-SNAIL (SNAI1) (AA 1-100) antibody
SNAI1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) (C-Term) antibodySNAI1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) (C-Term) antibodySNAI1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) (N-Term) antibodySNAI1 适用: 人, 小鼠, 大鼠, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) (AA 121-230) antibodySNAI1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G11 unconjugated
anti-SNAIL (SNAI1) (AA 1-264) antibodySNAI1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) (AA 9-39), (N-Term) antibodySNAI1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01400 unconjugated
anti-SNAIL (SNAI1) antibodySNAI1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) antibodySNAI1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SNAIL (SNAI1) antibodySNAI1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB:1:500-1:1000, IF:1:100-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- SNAIL (SNAI1)
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别名
- SNAI1
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背景
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Background:
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Okubo T., Cancer Res. 61:1338-1346(2001).
Twigg S.R., Hum. Genet. 105:320-326(1999).
Paznekas W.A., Genomics 62:42-49(1999).Aliases: dJ710H13.1 antibody, Protein sna antibody, Protein snail homolog 1 antibody, Protein snail homolog antibody, SLUGH2 antibody, SNA antibody, Sna protein antibody, SNAH antibody, SNAI antibody, snai1 antibody, SNAI1_HUMAN antibody, Snail 1 homolog antibody, Snail 1 zinc finger protein antibody, SNAIL antibody, Snail family transcriptional repressor 1 antibody, Snail homolog 1 (Drosophila) antibody, SNAIL, Drosophila, homolog of, 1 antibody, SNAIL1 antibody, Zinc finger protein SNAI1 antibody
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UniProt
- O95863
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途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
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