ILK 抗体 (pSer246)
Quick Overview for ILK 抗体 (pSer246) (ABIN7138506)
抗原
See all ILK 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- pSer246
-
交叉反应
- 人, 小鼠, 大鼠
-
纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
-
免疫原
- Peptide sequence around phosphorylation site of Serine 246(I-F-S(p)-H-P) derived from Human ILK.
-
亚型
- IgG
-
-
-
-
应用备注
- IHC:1:50-1:100,
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- ILK (Integrin-Linked Kinase (ILK))
-
别名
- ILK
-
背景
-
Background:
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
Hannigan G.E., Nature 379:91-96(1996).
Janji B., Oncogene 19:3069-3077(2000).
Tadic B., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.Aliases: 59 kDa serine/threonine protein kinase antibody, 59 kDa serine/threonine-protein kinase antibody, DKFZp686F1765 antibody, Epididymis secretory protein Li 28 antibody, HEL S 28 antibody, ILK 1 antibody, ILK 2 antibody, ILK antibody, ILK-1 antibody, ILK-2 antibody, ILK_HUMAN antibody, ILK1 antibody, ILK2 antibody, Integrin linked kinase 2 antibody, Integrin linked Kinase antibody, Integrin linked protein kinase antibody, Integrin-linked protein kinase antibody, p59 antibody, p59ILK antibody
-
UniProt
- Q13418
-
途径
- Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Smooth Muscle Cell Migration
抗原
-