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- 抗原 See all GFI1B 抗体
- GFI1B (Growth Factor Independent 1B Transcription Repressor (GFI1B))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GFI1B antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- 免疫原
- Peptide sequence around aa.322~326(H-R-E-S-Q) derived from Human GFI1b.
- 亚型
- IgG
- Top Product
- Discover our top product GFI1B Primary Antibody
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anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (N-Term) antibody
GFI1B 适用: 人, 小鼠, 大鼠, Cow, 犬, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (Internal Region) antibodyGFI1B 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (N-Term) antibodyGFI1B 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 山羊, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) antibodyGFI1B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (AA 2-110) antibodyGFI1B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (AA 1-330) antibodyGFI1B 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (Internal Region) antibodyGFI1B 适用: 人 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (AA 302-330), (C-Term) antibodyGFI1B 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB44051 unconjugated
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- 应用备注
- WB:1:500-1:1000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- GFI1B (Growth Factor Independent 1B Transcription Repressor (GFI1B))
- 别名
- GFI1B (GFI1B 产品)
- 背景
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Background:
Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context, represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1, GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription, as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.
Osawa M., Yamaguchi T., Nakamura Y. Iwama A.Blood 100:2769-2777(2002)
Huang D.-Y., Kuo Y.-Y., Chang Z.-F. Nucleic Acids Res. 33:5331-5342(2005)
Vassen L., Fiolka K., Moeroey T. EMBO J. 25:2409-2419(2006)Aliases: GFI 1B antibody, gfi1b antibody, GFI1B protein antibody, GFI1B_HUMAN antibody, Growth factor independent 1B protein antibody, Growth factor independent 1B transcription repressor antibody, Growth factor independent protein 1B antibody, OTTHUMP00000022443 antibody, OTTHUMP00000022444 antibody, OTTHUMP000000235527 antibody, Potential regulator of CDKN1A antibody, Potential regulator of CDKN1A translocated in CML antibody, Translocated in CML antibody, Zinc finger protein Gfi-1b antibody
- UniProt
- Q5VTD9
- 途径
- Cellular Response to Molecule of Bacterial Origin
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