GFI1B 抗体 (C-Term)
(2 references)-
- 抗原 See all GFI1B 抗体
- GFI1B (Growth Factor Independent 1B Transcription Repressor (GFI1B))
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抗原表位
- AA 302-330, C-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GFI1B antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This GFI1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human GFI1B.
- 克隆位点
- RB44051
- 亚型
- Ig Fraction
- Top Product
- Discover our top product GFI1B Primary Antibody
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anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (N-Term) antibody
GFI1B 适用: 人, 小鼠, 大鼠, Cow, 犬, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (Internal Region) antibodyGFI1B 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (N-Term) antibodyGFI1B 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (N-Term) antibodyGFI1B 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 山羊, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) antibodyGFI1B 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) antibodyGFI1B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (AA 2-110) antibodyGFI1B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (AA 1-330) antibodyGFI1B 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (Internal Region) antibodyGFI1B 适用: 人 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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: "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene." in: Nucleic acids research, Vol. 32, Issue 13, pp. 3935-46, (2004) (PubMed).
: "The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases." in: Genomics, Vol. 54, Issue 3, pp. 580-2, (1999) (PubMed).
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: "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene." in: Nucleic acids research, Vol. 32, Issue 13, pp. 3935-46, (2004) (PubMed).
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- 抗原
- GFI1B (Growth Factor Independent 1B Transcription Repressor (GFI1B))
- 别名
- GFI1B (GFI1B 产品)
- 别名
- GFI1B antibody, GFI antibody, znf544 antibody, MGC80648 antibody, Gfi-1B antibody, growth factor independent 1B transcriptional repressor antibody, growth factor independent 1B transcription repressor L homeolog antibody, Zinc finger protein Gfi-1b antibody, growth factor independent 1B antibody, GFI1B antibody, Gfi1b antibody, gfi1b.L antibody, gfi1b antibody
- 背景
- Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context, represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1, GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription, as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.
- 分子量
- 37492
- NCBI登录号
- NP_001128503, NP_004179
- UniProt
- Q5VTD9
- 途径
- Cellular Response to Molecule of Bacterial Origin
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