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LIN28A 抗体 (AA 1-5)

LIN28A 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7137921
发货至: 中国
  • 抗原 See all LIN28A 抗体
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    抗原表位
    • 15
    • 9
    • 9
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-5
    适用
    • 97
    • 31
    • 28
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 83
    • 18
    克隆类型
    • 77
    • 24
    多克隆
    标记
    • 51
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LIN28A antibody is un-conjugated
    应用范围
    • 66
    • 38
    • 26
    • 23
    • 19
    • 14
    • 13
    • 13
    • 10
    • 10
    • 9
    • 3
    • 3
    • 1
    Western Blotting (WB), ELISA
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
    免疫原
    Peptide sequence around aa. 1~5 (M-G-S-V-S) derived from Human Lin28
    亚型
    IgG
    Top Product
    Discover our top product LIN28A Primary Antibody
  • 应用备注
    WB:1:500-1:1000,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    别名
    LIN28A (LIN28A 产品)
    背景

    Background: Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.

    Heo I., Joo C., Mol. et al., Cell 32:276-284(2008)
    Heo I., Joo C., Kim Y.-K., et al., Cell 138:696-708(2009)
    Viswanathan S.R., Powers J.T., et al., Nat. Genet. 41:843-848(2009)

    Aliases: AL024421 antibody, CSDD1 antibody, CSDD2 antibody, FLJ12457 antibody, Lin 28 antibody, Lin 28 homolog (C. elegans) antibody, Lin 28 homolog A (C. elegans) antibody, Lin 28 homolog A antibody, Lin 28 homolog antibody, Lin-28A antibody, Lin28 antibody, Lin28, C. elegans, homolog of, A antibody, LIN28A antibody, LN28A_HUMAN antibody, Protein lin-28 homolog A antibody, Protein lin-28 homolog B antibody, RNA binding protein lin 28 antibody, Tex17 antibody, ZCCHC1 antibody, Zinc finger CCHC domain containing 1 antibody, Zinc finger CCHC domain containing protein 1 antibody, Zinc finger CCHC domain-containing protein 1 antibody

    UniProt
    Q9H9Z2
    途径
    Stem Cell Maintenance
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