Recombinant YY1 抗体
Quick Overview for Recombinant YY1 抗体 (ABIN7127872)
抗原
See all YY1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human YY1
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亚型
- IgG
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anti-YY1 Transcription Factor (YY1) (AA 221-320) antibody
YY1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4A5 unconjugated
anti-YY1 Transcription Factor (YY1) antibodyYY1 适用: 人 WB, IP, IF, ChIP 宿主: 兔 Monoclonal unconjugated
anti-YY1 Transcription Factor (YY1) (AA 1-414) antibodyYY1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-YY1 Transcription Factor (YY1) antibodyYY1 适用: 人, 大鼠, 斑马鱼, Cynomolgus WB, IHC (p) 宿主: 小鼠 Monoclonal 1183CT6-5-23-6 unconjugated
anti-YY1 Transcription Factor (YY1) (full length) antibodyYY1 适用: 人, 小鼠, 大鼠, Pig WB, IF 宿主: 小鸡 Polyclonal unconjugated
anti-YY1 Transcription Factor (YY1) (AA 221-321) antibodyYY1 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2C4 unconjugated
anti-YY1 Transcription Factor (YY1) (AA 1-414) antibodyYY1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-YY1 Transcription Factor (YY1) (AA 274-323) antibodyYY1 适用: 人, 小鼠, 大鼠, 犬, Cow, 绵羊, Pig, 小鸡, 猴, 马, 兔, 非洲爪蟾, 豚鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-YY1 Transcription Factor (YY1) (AA 1-200) antibodyYY1 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-YY1 Transcription Factor (YY1) (AA 74-104), (N-Term) antibodyYY1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB2943 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- YY1 (YY1 Transcription Factor (YY1))
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别名
- YY1
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背景
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Background: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3', some genes have been shown to contain a longer binding motif allowing enhanced binding, the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647).
Aliases: Transcriptional repressor protein YY1, Delta transcription factor, INO80 complex subunit S, NF-E1, Yin and yang 1, YY-1, YY1, INO80S
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UniProt
- P25490
抗原
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