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Recombinant HSF1 抗体 (pSer326)

Name: Recombinant HSF1 抗体 (pSer326)
Brand: antibodies-online
SKU: ABIN7127699
Availability: OutOfStock

This anti-HSF1 antibody is a 兔单克隆 antibody detecting HSF1 in WB, ELISA 和 ICC. Suitable for 人.

Western Blot Positive WB detected in Hela whole cell lysate All lanes Phospho-HSF1 antibody at 0. (Recombinant HSF1 抗体 (pSer326))

Immunocytochemistry analysis of ABIN7127699 diluted at 1:80 and staining in Hela cells performed on a Leica BondTM system. (Recombinant HSF1 抗体 (pSer326))

ICC

2 images

产品编号 ABIN7127699

发货至: 中国

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中国
北京 101111

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Beijing Economic Technological Development Area

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4A Biotech Co.,Ltd.

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Quick Overview for Recombinant HSF1 抗体 (pSer326) (ABIN7127699)

抗原

See all HSF1 抗体

HSF1 (Heat Shock Factor Protein 1 (HSF1))

抗体类型

Recombinant Antibody

适用

人

宿主

兔

克隆类型

单克隆

标记

This HSF1 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

克隆位点

2A7

Discover our top product HSF1 Primary Antibody

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pSer326

原理

Phospho-HSF1 (S326) Recombinant Monoclonal Antibody

纯化方法

Affinity-chromatography

免疫原

A synthesized peptide derived from human Phospho-HSF1 (S326)

亚型

IgG
anti-Heat Shock Factor Protein 1 (HSF1) (AA 378-395) antibody (HRP)
HSF1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC, GS 宿主: 大鼠 Monoclonal 10H8 HRP

anti-Heat Shock Factor Protein 1 (HSF1) (AA 378-395) antibody (FITC)
HSF1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC, GS 宿主: 大鼠 Monoclonal 10H8 FITC

anti-Heat Shock Factor Protein 1 (HSF1) (AA 378-395) antibody (Biotin)
HSF1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC, GS 宿主: 大鼠 Monoclonal 10H8 Biotin

anti-Heat Shock Factor Protein 1 (HSF1) (AA 378-395) antibody (PE)
HSF1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC, GS 宿主: 大鼠 Monoclonal 10H8 PE

anti-Heat Shock Factor Protein 1 (HSF1) (AA 378-395) antibody (APC)
HSF1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC, GS 宿主: 大鼠 Monoclonal 10H8 APC

anti-Heat Shock Factor Protein 1 (HSF1) (AA 378-395) antibody (PerCP)
HSF1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC, GS 宿主: 大鼠 Monoclonal 10H8 PerCP

anti-Heat Shock Factor Protein 1 (HSF1) (AA 378-395) antibody (Atto 488)
HSF1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC, GS 宿主: 大鼠 Monoclonal 10H8 Atto 488

anti-Heat Shock Factor Protein 1 (HSF1) (AA 378-395) antibody (Atto 594)
HSF1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC, GS 宿主: 大鼠 Monoclonal 10H8 Atto 594

anti-Heat Shock Factor Protein 1 (HSF1) (AA 378-395) antibody (Atto 390)
HSF1 适用: 小鼠 WB, ELISA, IHC, IP, IF, ICC, GS 宿主: 大鼠 Monoclonal 10H8 Atto 390

anti-Heat Shock Factor Protein 1 (HSF1) (AA 350-529) antibody
HSF1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB:1:500-1:5000, ICC:1:50-1:200

限制

仅限研究用
状态

Liquid

缓冲液

phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

HSF1 (Heat Shock Factor Protein 1 (HSF1))

别名

HSF1

背景

Background: Function as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage (PubMed:1871105, PubMed:11447121, PubMed:1986252, PubMed:7760831, PubMed:7623826, PubMed:8946918, PubMed:8940068, PubMed:9341107, PubMed:9121459, PubMed:9727490, PubMed:9499401, PubMed:9535852, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:25963659, PubMed:26754925). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:9727490, PubMed:11583998, PubMed:16278218). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:1871105, PubMed:1986252, PubMed:8455624, PubMed:7935471, PubMed:7623826, PubMed:8940068, PubMed:9727490, PubMed:9499401, PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:25963659, PubMed:26754925). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925).
Aliases: Heat shock factor protein 1, HSF 1, Heat shock transcription factor 1, HSF1

UniProt

Q00613