Recombinant LOXL2 抗体
Quick Overview for Recombinant LOXL2 抗体 (ABIN7127602)
抗原
See all LOXL2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
交叉反应
- 人, 小鼠, 大鼠
-
纯化方法
- Affinity-chromatography
-
免疫原
- A synthesized peptide derived from human LOXL2
-
亚型
- IgG
-
-
anti-Lysyl Oxidase-Like 2 (LOXL2) antibody
KO Validated LOXL2 适用: 人 WB, IHC, ELISA, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 544-751) antibodyLOXL2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysyl Oxidase-Like 2 (LOXL2) (Internal Region) antibodyLOXL2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 675-773) antibodyLOXL2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5D2 unconjugated
anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 53-160) antibodyLOXL2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 27-121) antibodyLOXL2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 675-773) antibodyLOXL2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 505-774) antibodyLOXL2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 553-761) antibodyLOXL2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 434-546) antibodyLOXL2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200, FC:1:20-1:200,
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))
-
别名
- LOXL2
-
背景
-
Background: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
Aliases: Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14), LOXL2
-
UniProt
- Q9Y4K0
-
途径
- Chromatin Binding
抗原
-
