CBFB 抗体
Quick Overview for CBFB 抗体 (ABIN7127112)
抗原
See all CBFB 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- The transcription factor polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (osteoblast-specific transcription factor), CBFA1 (core binding factor) and AML3 (acute myeloid leukemia), is composed of two subunits, i± and i², which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2i± subunits, PEBP2i±A, PEBP2i±B and PEBP2i±C, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, Runt. This region is involved in DNA binding and heterodimerization with the regulatory i² subunit, which facilitates DNA binding of the i± subunit. Both subunits are required for in vivo function, the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2i² is the target of chromosomal inversion 16 (p13,q22) with the smooth muscle Myosin heavy chain, producing a chimeric gene, PEBP2i²/CBFB-SMMHC, that is associated with human acute myeloid leukemia.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human CBFB protein
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亚型
- IgG2b
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anti-Core-Binding Factor, beta Subunit (CBFB) (AA 1-187) antibody
CBFB 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) (Internal Region) antibodyCBFB 适用: 人 ELISA, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) (N-Term) antibodyCBFB 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) (AA 1-182) antibodyCBFB 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) (AA 61-90) antibodyCBFB 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB21198 unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) (AA 1-182) antibodyCBFB 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) antibodyCBFB 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) (AA 1-182) antibodyCBFB 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, FACS, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) (AA 74-163) antibodyCBFB 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Core-Binding Factor, beta Subunit (CBFB) antibodyCBFB 适用: 人 WB, ICC, DB 宿主: 小鼠 Monoclonal 344C3a unconjugated
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应用备注
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Known_Application: ELISA (For coating, order antibody without BSA), Western Blot (1-2 μg/mL),Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, U87 or Jurkat cells.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- CBFB (Core-Binding Factor, beta Subunit (CBFB))
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别名
- CBFB
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背景
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CBF b; CBFB; Core-binding factor, beta subunit (CBFB), transcript variant 2; PEBP2 beta; PEBP2B; Polyomavirus enhancer binding protein 2 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit,CBFB / PEBP2β
Cellular localisation: Nucleus. Nucleoplasm. Cytoplasm. -
分子量
- 22kDa
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基因ID
- 865, 519632
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UniProt
- Q13951
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途径
- Regulation of Lipid Metabolism by PPARalpha
抗原
-
