TPO (AA 685-804) 抗体
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- 抗原
- TPO
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抗原表位
- AA 685-804
- 适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- 非结合性
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应用范围
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
- 交叉反应 （详细）
- Human.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant fragment of human TPO (around aa 685-804) (Exact sequence is proprietary)
- 亚型
- IgG2b
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anti-TPO antibody
适用: 人 IHC 宿主: 兔 Monoclonal unconjugated
anti-TPO (AA 685-804) antibody适用: 人 IHC, StM 宿主: 兔 Monoclonal TPO-3813R unconjugated Recombinant Antibody
anti-TPO (AA 685-804) antibody适用: 人 IHC, StM 宿主: 小鼠 Monoclonal TPO-1921 unconjugated
anti-TPO (AA 19-846) antibody适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-TPO antibody适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human thyroid carcinoma
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- TPO
- 物质类
- Viral Protein
- 背景
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MSA, TDH2A, Thyroid microsomal antigen, Thyroid peroxidase, Thyroperoxidase, TPO, TPX,TPO (Thyroid Peroxidase) (Thyroid Marker)
Cellular localisation: Cytoplasmic and cell surface - 分子量
- 100kDa
- 基因ID
- 7173, 467554
- UniProt
- P07202
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