SOD1 抗体 (AA 14-148)
Quick Overview for SOD1 抗体 (AA 14-148) (ABIN7126948)
抗原
See all SOD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 14-148
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特异性
- Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant fragment (around aa14-148) of human SOD1 (exact sequence is proprietary)
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亚型
- IgG1
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anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 1-154) antibody
SOD1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) antibodyKO Validated SOD1 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (C-Term) antibodyKO Validated SOD1 适用: 人 WB, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 2-154) antibodySOD1 适用: 人, 马 WB, IHC, IP, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 6-100) antibodySOD1 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IHC (p), FACS, IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 2-154) antibodySOD1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 2-154) antibodySOD1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 2-153) antibody (APC)SOD1 适用: 兔 WB, IHC 宿主: 豚鼠 Polyclonal APC
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 2-154) antibodySOD1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 2-153) antibodySOD1 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: LNCaP, JEG-3 or Jurkat cells. Human breast or ovarian carcinoma.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- SOD1 (Superoxide Dismutase 1, Soluble (SOD1))
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别名
- SOD1
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背景
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Amyotrophic lateral sclerosis 1 (ALS1), Cu/Zn SOD, Cu/Zn Superoxide Dismutase, Epididymis Secretory Protein Li 44, Indophenoloxidase A (IPOA), Superoxide Dismutase [Cu-Zn], Superoxide Dismutase 1 (SOD1),Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme)
Cellular localisation: Cytoplasm -
分子量
- 16kDa
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基因ID
- 6647, 443914
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UniProt
- P00441
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途径
- Sensory Perception of Sound, Transition Metal Ion Homeostasis
抗原
-
