Recombinant KRT14 抗体 (AA 350-472)
Quick Overview for Recombinant KRT14 抗体 (AA 350-472) (ABIN7126632)
抗原
See all KRT14 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 350-472
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特异性
- Cytokeratin 14 is a member of the type I keratin family of intermediate filament proteins. It always pairs with the type II keratin K5 and form the primary keratin pair of the keratinocytes of stratified squamous epithelia, including the epidermis as well as mucosal non-keratinizing stratified squamous epithelia.Cytokeratin 14 is strongly expressed in the undifferentiated basal cell layer containing the stem cells and are down-regulated in the differentiating suprabasal cell layers. Otherwise, in the widely well stratified follicular outer root sheath, cytokeratin 14 is uniformly expressed throughout all layers. The expression spectrum of cytokeratin 14 in tumors corresponds well to the patterns in normal epithelia. Thus, most squamous cell carcinomas as well as malignant mesotheliomas strongly express this keratin whereas little, focal, or no expression is found in adenocarcinomas.Cytokeratin 14 may be a useful marker in the differential diagnosis of squamous cell carcinoma from other epithelial tumors. Recent studies also indicate that CK14 expression in breast cancer corresponded with poor clinical outcome and that CK14 may have diagnostic value in the sub-classification of NSCLC.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human KRT14 fragment (around aa350-472) (exact sequence is proprietary)
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亚型
- IgG
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anti-Keratin 14 (KRT14) antibody
KRT14 适用: 人 WB, IHC, IF, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Keratin 14 (KRT14) antibodyKRT14 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Keratin 14 (KRT14) (AA 1-484) antibodyKRT14 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Keratin 14 (KRT14) (C-Term) antibodyKRT14 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Keratin 14 (KRT14) (C-Term) antibodyKRT14 适用: 人, 大鼠, 小鼠 IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal LL002 unconjugated
anti-Keratin 14 (KRT14) (AA 351-472) antibodyKRT14 适用: 人, 大鼠, 小鼠, Pig IHC, FACS, StM 宿主: 小鼠 Monoclonal KRT14-2375 unconjugated
anti-Keratin 14 (KRT14) antibodyKRT14 适用: 人, 大鼠, Pig, 犬 WB, IHC, FACS, ICC, IHC (fro) 宿主: 小鼠 Monoclonal RCK107 unconjugated
anti-Keratin 14 (KRT14) (C-Term) antibodyKRT14 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Keratin 14 (KRT14) antibodyKRT14 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Keratin 14 (KRT14) (AA 276-303) antibodyKRT14 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: A431 orHeLacells. Human prostate, skin or squamous cell carcinoma.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- KRT14 (Keratin 14 (KRT14))
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别名
- KRT14
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背景
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CK-14, Dowling Meara, ebs3, ebs4, Epidermolysis Bullosa Simplex, k14, Keratin 14, Keratin Type I Cytoskeletal 14, Koebner, krt14, NFJ,Cytokeratin 14 (KRT14) (Squamous Cell Marker)
Cellular localisation: Cytoplasm. -
分子量
- 50kDa
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基因ID
- 3861, 6545380
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UniProt
- P02533
抗原
-
