FTH1 抗体 (AA 58-180)
Quick Overview for FTH1 抗体 (AA 58-180) (ABIN7126443)
抗原
See all FTH1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 58-180
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特异性
- Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidationof FeI(II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of aging-related cataracts.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human FTH1 protein fragment (around aa 58-180) (exact sequence is proprietary)
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亚型
- IgG2
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anti-Ferritin, Heavy Polypeptide 1 (FTH1) (AA 1-183) antibody
FTH1 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ferritin, Heavy Polypeptide 1 (FTH1) antibodyFTH1 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Ferritin, Heavy Polypeptide 1 (FTH1) (AA 1-181) antibodyFTH1 适用: Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ferritin, Heavy Polypeptide 1 (FTH1) (C-Term) antibodyVerified FTH1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Ferritin, Heavy Polypeptide 1 (FTH1) (AA 1-183) antibodyFTH1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ferritin, Heavy Polypeptide 1 (FTH1) (AA 1-100) antibodyFTH1 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ferritin, Heavy Polypeptide 1 (FTH1) (AA 1-183) antibodyFTH1 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal D4 unconjugated
anti-Ferritin, Heavy Polypeptide 1 (FTH1) (AA 58-180) antibodyFTH1 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal FTH-2081 unconjugated
anti-Ferritin, Heavy Polypeptide 1 (FTH1) (C-Term) antibodyFTH1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ferritin, Heavy Polypeptide 1 (FTH1) antibodyFTH1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
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应用备注
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Known_Application: Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human liver tissue. Liver tissue lysate.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- FTH1 (Ferritin, Heavy Polypeptide 1 (FTH1))
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别名
- FTH1
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背景
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Apoferritin, Cell proliferation-inducing gene 15 protein, Ferritin H subunit, Ferritin heavy chain, FHC, FRIH, FTH1, FTHL6, Iron overload autosomal dominant, PIG15, Placenta immunoregulatory factor, Proliferation inducing gene 15 protein (PLIF),Ferritin, Heavy Chain (FTH) (Microglia Marker)
Cellular localisation: Cytoplasmic -
分子量
- 21kDa
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基因ID
- 2495
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UniProt
- P02794
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途径
- Transition Metal Ion Homeostasis
抗原
-
