RHOBTB2 抗体 (AA 554-604)
Quick Overview for RHOBTB2 抗体 (AA 554-604) (ABIN7126412)
抗原
See all RHOBTB2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 554-604
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特异性
- The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. DBC-2 (deleted in breast cancer 2 gene protein), also known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. Expressed ubiquitously with highest levels in neural tissue, heart, brain and fetal lung, DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate the function of target proteins, such as CUL-3. Additionally, DBC-2 is thought to function as a regulator of cell cycle and apoptosis events. Under normal conditions, DBC-2 is thought to exhibit tumor suppressor activity. Mutations in the gene encoding DBC-2 are associated with breast cancer, suggesting that mutated DBC-2 may play a role in carcinogenesis.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Human recombinant RHOBTB2 protein fragment (around aa 554-604) (exact sequence is proprietary)
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亚型
- IgG2b
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anti-rho-Related BTB Domain Containing 2 (RHOBTB2) (AA 631-727) antibody
RHOBTB2 适用: 人 ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-rho-Related BTB Domain Containing 2 (RHOBTB2) antibodyRHOBTB2 适用: 人, 小鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-rho-Related BTB Domain Containing 2 (RHOBTB2) (AA 61-110) antibodyRHOBTB2 适用: 人, 小鼠 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-rho-Related BTB Domain Containing 2 (RHOBTB2) (AA 510-619) antibodyRHOBTB2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2G6 unconjugated
anti-rho-Related BTB Domain Containing 2 (RHOBTB2) (AA 1-727) antibodyRHOBTB2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-rho-Related BTB Domain Containing 2 (RHOBTB2) (N-Term) antibodyRHOBTB2 适用: 人, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-rho-Related BTB Domain Containing 2 (RHOBTB2) (AA 61-110) antibodyRHOBTB2 适用: 人, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human heart muscle or brain tissue.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))
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别名
- RHOBTB2
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背景
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Deleted in breast cancer 2 gene protein, p83, Rho related BTB domain containing protein 2,DBC2 / RHOBTB2
Cellular localisation: Secreted in plasma -
分子量
- 83kDa
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基因ID
- 23221, 372688
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UniProt
- Q9BYZ6
抗原
-
