Endoglin 抗体
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北京 101111
Quick Overview for Endoglin 抗体 (ABIN7126335)
抗原
See all Endoglin (ENG) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Endoglin / CD105 (Angiogenesis Marker) Antibody
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特异性
- CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
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交叉反应 （详细）
- Human, Monkey, Horse, Pig and Rat.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant extracellular fragment of human Endoglin protein exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-Endoglin (ENG) (AA 58-110) antibody
ENG 适用: 人, 小鼠, 大鼠, 犬 WB, FACS, ELISA, IHC (fro), IHC (p), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Endoglin (ENG) (AA 27-137) antibodyENG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endoglin (ENG) (AA 26-136) antibodyENG 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endoglin (ENG) (AA 26-136) antibodyENG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endoglin (ENG) antibodyENG 适用: 人 FACS, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 3A9 unconjugated
anti-Endoglin (ENG) (AA 27-226) antibodyENG 适用: 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Endoglin (ENG) (AA 601-658) antibodyENG 适用: 人, 大鼠 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Endoglin (ENG) antibody (APC)ENG 适用: 人, 大鼠 FACS 宿主: 小鼠 Monoclonal MEM-226 APC
anti-Endoglin (ENG) antibodyENG 适用: 人, 大鼠 WB, FACS, IP, MS 宿主: 小鼠 Monoclonal MEM-226 unconjugated
anti-Endoglin (ENG) (AA 27-658) antibodyENG 适用: 人 WB, IP, ELISA 宿主: 小鼠 Monoclonal 4C11 unconjugated
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应用备注
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Known_Application: ELISA (For coating, order antibody without BSA), Functional Assays (order antibody without BSA and azide), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (2-4 μg/mL) Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, A431 or HL-60 cells.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8È105ü79oΩC. Antibody without azide - store at -20 to -80È105ü79oΩC. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- Endoglin (ENG)
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别名
- ENG
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背景
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CD105, END, Endoglin, Eng, HHT1, S-endoglin
A431 or HL-60 cells., HeLa
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分子量
- 80kDa (Monomer), 160kDa (Homodimer)
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基因ID
- 2022, 76753
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UniProt
- P17813
抗原
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