SMNDC1 抗体
Quick Overview for SMNDC1 抗体 (ABIN7126174)
抗原
See all SMNDC1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (survival motor neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human SMNDC1 protein
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亚型
- IgG2b
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anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) antibody
SMNDC1 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (AA 1-238) antibodySMNDC1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) antibodySMNDC1 适用: 人 FACS, IF 宿主: 小鼠 Monoclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (AA 1-238) antibodySMNDC1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2B9 unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (AA 1-238) antibodySMNDC1 适用: 人 ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (AA 1-238) antibodySMNDC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) antibodySMNDC1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (C-Term) antibodySMNDC1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠, 山羊, 马, 小鸡, Pig, 非洲爪蟾, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (C-Term) antibodySMNDC1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Survival Motor Neuron Domain Containing 1 (SMNDC1) (AA 11-41), (N-Term) antibodySMNDC1 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB17335 unconjugated
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应用备注
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa or HepG2 cells.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))
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别名
- SMNDC1
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背景
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30 kDa splicing factor SMNrp, MGC106917, MGC112663, SMN related protein, SMNR, SPF30, Splicing factor 30, survival of motor neuron-related, Survival motor neuron domain containing protein 1, Survival of motor neuron related splicing factor 30,SMNDC1
Cellular localisation: Nucleus. Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies. -
分子量
- 30kDa
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基因ID
- 10285, 632093
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UniProt
- O75940
抗原
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