ZCCHC11 抗体
Quick Overview for ZCCHC11 抗体 (ABIN7121051)
抗原
See all ZCCHC11 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- zinc finger, CCHC domain containing 11
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亚型
- IgG
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anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1-290) antibody
ZCCHC11 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (Internal Region) antibodyZCCHC11 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1403-1452) antibodyZCCHC11 适用: 人, 犬, Cow, 豚鼠, Bat, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1-309) antibodyZCCHC11 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (C-Term) antibodyVerified ZCCHC11 适用: 人 ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (Internal Region) antibodyVerified ZCCHC11 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1568-1600), (C-Term) antibodyZCCHC11 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51164 unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1-309) antibodyZCCHC11 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (Middle Region) antibodyZCCHC11 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:200-1:2000, IP: 1:500-1:5000, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))
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别名
- ZCCHC11
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背景
- Synonyms:KIAA0191, PAPD3, Terminal uridylyltransferase 4, TUT4, TUTase 4, ZCCHC11 Background:Uridylyltransferase that mediates the terminal uridylation of mRNAs with short(less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay(PubMed:25480299). Involved in microRNA(miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7(pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem(ES) cell pluripotency(By similarity). Does not bind RNA directly, but recruited to RNA targets by RNA-binding protein LIN28A. Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression(By similarity). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.
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分子量
- 185 kDa
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基因ID
- 23318
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UniProt
- Q5TAX3
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途径
- Stem Cell Maintenance
抗原
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